Switch #:
SWTI000330
Switch type:
Specificity
Switch subtype:
Domain hiding

Description:
Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).

Participants:
(1) Cyclin-dependent kinase inhibitor 1B (CDKN1B)
(2) Cyclin-A2 (CCNA2)
(3) Cell division control protein 6 homolog (CDC6)

Interactions
Interaction #1 CDKN1B - CCNA2

Is mutually exclusive with Interaction #2 CDC6 - CCNA2

Interfaces
(1) DOC_CYCLIN_1 motif () in Cyclin-dependent kinase inhibitor 1B (CDKN1B)
(2) Cyclin, N-terminal domain (181-307) in Cyclin-A2 (CCNA2)
Interaction #2 CDC6 - CCNA2

Is mutually exclusive with Interaction #1 CDKN1B - CCNA2

Interfaces
(3) DOC_CYCLIN_1 motif (94RRLVF98) in Cell division control protein 6 homolog (CDC6)
(4) Cyclin, N-terminal domain (181-307) in Cyclin-A2 (CCNA2)

Interaction Regulation
Effector binding Abrogation (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) of the Cell division control protein 6 homolog (CDC6) DOC_CYCLIN_1 motif - Cyclin-A2 (CCNA2) Cyclin, N-terminal domain interaction

Context
References

(1) Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21.
Wang et al. Nat. Chem. Biol. (2011)




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