Description: An intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).
Participants: (1) Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) (2) Myc proto-oncogene protein (MYC)
(1) A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.Pineda-Lucena et al. J. Mol. Biol. (2005)
Your browser does not support iframes.