Switch #:
SWTI000321
Switch type:
Specificity
Switch subtype:
Motif hiding

Description:
Interaction of the GABA receptor R2 subunit (Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)) with the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)) via coiled-coil forming domains masks the ER retention motif in the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)), thereby promoting surface expression of fully assembled GABA receptors.

Participants:
(1) Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)
(2) Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)
(3) Coatomer subunit beta (COPB1)

Interactions
Interaction #1 GABBR1 - GABBR2

Is mutually exclusive with Interaction #2 GABBR1 - COPB1

Interfaces
(1) OTHER:coiled coil in Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)
(2) Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)
Interaction #2 GABBR1 - COPB1

Is mutually exclusive with Interaction #1 GABBR1 - GABBR2

Interfaces
(3) TRG_ER_diArg_1 motif (923RSRR926) in Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)
(4) Adaptin N terminal region (18-539) in Coatomer subunit beta (COPB1)

Interaction Regulation
Effector binding Abrogation (Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)) of the Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) TRG_ER_diArg_1 motif - Coatomer subunit beta (COPB1) Adaptin N terminal region interaction

Context
Switch localisation
ELM curated: rough endoplasmic reticulum, endoplasmic reticulum cisterna, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane
Inferred: integral to plasma membrane, postsynaptic membrane, cell junction


Switch pathways
Inferred: Neuroactive ligand-receptor interaction, GABAergic synapse
References

(1) Hide and run. Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins.
Michelsen et al. EMBO Rep. (2005)




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