Description: The basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.
Participants: (1) HLA class II histocompatibility antigen gamma chain (CD74) (2) 14-3-3 protein beta/alpha (YWHAB) (3) Coatomer subunit beta (COPB1)
(1) Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.O'Kelly et al. Cell (2002)
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