Description: Hiding of the NLS of MKL/myocardin-like protein 1 (Mkl1) by binding of G-actin to the RPEL motifs of MKL/myocardin-like protein 1 (Mkl1) prevents translocation of this transcription factor to the nucleus.
Participants: (1) MKL/myocardin-like protein 1 (Mkl1) (2) Actin, alpha skeletal muscle (Acta1) (3) Importin subunit alpha-3 (Kpna3)
(1) An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.Pawłowski et al. EMBO J. (2010) (2) Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.Mouilleron et al. Sci Signal (2011)
Your browser does not support iframes.