Switch #:
SWTI000317
Switch type:
Specificity
Switch subtype:
Motif hiding

Description:
Phosphorylation-induced binding of dimeric 14-3-3 protein beta/alpha (YWHAB) to Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) blocks ER retention motifs in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) and regulates transport of this protein to the membrane.

Participants:
(1) Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
(2) 14-3-3 protein beta/alpha (YWHAB)
(3) Coatomer subunit beta (COPB1)

Interactions
Interaction #1 ADAM22 - YWHAB

Is mutually exclusive with Interaction #2 ADAM22 - COPB1

Interfaces
(1) LIG_14-3-3_3 motif (831RSNSWQ836 and 854RSNSTE859) in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
(2) 14-3-3 protein (5-238) in 14-3-3 protein beta/alpha (YWHAB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S834 and S857 on Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)) of the Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) LIG_14-3-3_3 motif - 14-3-3 protein beta/alpha (YWHAB) 14-3-3 protein interaction

Context
References

(1) Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.
Gödde et al. J. Cell. Sci. (2006)




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