Description: Inhibition of nuclear import of DNA polymerase processivity factor (UL44) by phosphorylation-dependent (T427) binding of BRCA1-associated protein (BRAP).
Participants: (1) DNA polymerase processivity factor (UL44) (2) BRCA1-associated protein (BRAP) (3) Importin subunit alpha-1 (KPNA1)
(1) The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal.Fulcher et al. FASEB J. (2010) (2) Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.Li et al. J. Biol. Chem. (1998)
