Description: Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).
Participants: (1) Amyloid beta A4 protein (APP) (2) Amyloid beta A4 precursor protein-binding family B member 1 (APBB1) (3) Growth factor receptor-bound protein 2 (GRB2)
(1) The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.Tamayev et al. Mol Neurodegener (2009) (2) Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.Zhou et al. J. Alzheimers Dis. (2009)
