Description: Phosphorylation of S775 switches binding specificity of Ataxin-1 (ATXN1) from the splicing factor Splicing factor U2AF 65 kDa subunit (U2AF2) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)). While association with the spliceosome protects ATXN1 from self-association, its phosphorylation-dependent recruitment to 14-3-3 proteins (e.g. YWHAZ) might result in aggregation.
Participants: (1) Ataxin-1 (ATXN1) (2) Splicing factor U2AF 65 kDa subunit (U2AF2) (3) 14-3-3 protein zeta/delta (YWHAZ)
(1) Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.de Chiara et al. PLoS ONE (2009)
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