Description: Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by c-Src (SRC) switches the specificity of DAG1 from WW domain containing proteins like Utrophin (UTRN) to SH2 domain containing proteins like Tyrosine-protein kinase CSK (CSK).
Participants: (1) Dystroglycan (DAG1) (2) Utrophin (UTRN) (3) Tyrosine-protein kinase CSK (CSK)
(1) Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin.James et al. J. Cell. Sci. (2000) (2) Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.Sotgia et al. Biochemistry (2001)
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