Description: Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).
Participants: (1) Integrin beta-2 (ITGB2) (2) Filamin-A (FLNA) (3) 14-3-3 protein zeta/delta (YWHAZ)
(1) Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.Takala et al. Blood (2008)
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