Description: Participants: Interactions  This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step1Interaction #1 FGD1 - GSK3B Is mutually exclusive with Interaction #2 FGD1 - BTRC Interfaces (1) MOD_GSK3_1 motif (280NRDSGIDS287) in FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) (2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B) Interaction Regulation PTM-dependent Induction (Phosphorylation of S287 on FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)) of the FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction 2Interaction #2 FGD1 - BTRC Requires Interaction #1 FGD1 - GSK3B Is mutually exclusive with Interaction #1 FGD1 - GSK3B Interfaces (3) DEG_SCF_TRCP1_1 motif (282DSGIDS287) in FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) (4) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC) Interaction Regulation PTM-dependent Induction (Phosphorylation of S283 and S287 on FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)) of the FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction Regulatory Enzymes for switch Modifying enzymes for residue: S283: Glycogen synthase kinase-3 beta (GSK3B) Context References (1) The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1. |
|
