Switch #:
SWTI000275
Switch type:
Cumulative
Switch subtype:
Rheostatic

Description:
While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction.

Participants:
(1) Integrin beta-3 (ITGB3)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 ITGB3 - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (779TFTNITY785) in Integrin beta-3 (ITGB3)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Enhancement (Phosphorylation of Y785 and Y773 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction


Additional Information
Structural information: 2L1C
Context
References

(1) Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling.
Cowan et al. J. Biol. Chem. (2000)

(2) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh et al. J. Biol. Chem. (2010)




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