Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to Neural Wiskott-Aldrich syndrome protein (WASL) allosterically relieves an auto-inhibitory intramolecular interaction in Neural Wiskott-Aldrich syndrome protein (WASL), which becomes active.
Participants: (1) Neural Wiskott-Aldrich syndrome protein (WASL)
(1) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.Rohatgi et al. J. Cell Biol. (2000) (2) Physical mechanisms of signal integration by WASP family proteins.Padrick et al. Annu. Rev. Biochem. (2010) (3) Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.Prehoda et al. Science (2000)
