Switch #:
SWTI000267
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to Wiskott-Aldrich syndrome protein (WAS) allosterically relieves an auto-inhibitory intramolecular interaction in Wiskott-Aldrich syndrome protein (WAS), which becomes active.

Participants:
(1) Wiskott-Aldrich syndrome protein (WAS)

Interactions
Interaction #1 WAS - WAS(intramolecular)
intramolecular
Interfaces
(1) ELM:LIG_GBD_WASP_1 motif (466LVGALMHVMQK476) in Wiskott-Aldrich syndrome protein (WAS)
(2) P21-Rho-binding domain (237-296) in Wiskott-Aldrich syndrome protein (WAS)

Interaction Regulation
Effector binding Inhibition (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the Wiskott-Aldrich syndrome protein (WAS) LIG_GBD_WASP_1 motif - Wiskott-Aldrich syndrome protein (WAS) P21-Rho-binding domain interaction

Additional Information
Structural information: 1EJ5
References

(1) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.
Rohatgi et al. J. Cell Biol. (2000)

(2) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

(3) Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.
Prehoda et al. Science (2000)

(4) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Kim et al. Nature (2000)




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