Description: Binding of the 3,3',5-triiodo-L-thyronine ligand to the nuclear Thyroid hormone receptor alpha (THRA) makes the binding site for the NRBOX motif of Mediator of RNA polymerase II transcription subunit 1 (MED1) accessible.
Participants: (1) Mediator of RNA polymerase II transcription subunit 1 (MED1) (2) Thyroid hormone receptor alpha (THRA)
(1) An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.Coulthard et al. J. Biol. Chem. (2003) (2) The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.Yuan et al. Proc. Natl. Acad. Sci. U.S.A. (1998) (3) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.Malik et al. Mol. Cell. Biol. (2004)
