Switch #:
SWTI000249
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of the leukotriene D4 ligand to the nuclear Peroxisome proliferator-activated receptor alpha (PPARA) makes the binding site for the CORNRBOX motif of Nuclear receptor corepressor 2 (NCOR2) inaccessible.

Participants:
(1) Nuclear receptor corepressor 2 (NCOR2)
(2) Peroxisome proliferator-activated receptor alpha (PPARA)

Interactions
Context
Switch localisation
Curated: nucleus
ELM curated: nucleus
References

(1) Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Xu et al. Nature (2002)




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