Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Beta-secretase 1 (BACE1) via an endocytosis motif.
Participants: (1) Beta-secretase 1 (BACE1) (2) AP-2 complex subunit sigma (AP2S1)
(1) Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.Shiba et al. Traffic (2004)
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