Switch #:
SWTI000241
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Delta-type opioid receptor (OPRD1) via an endocytosis motif.

Participants:
(1) Delta-type opioid receptor (OPRD1)
(2) AP-2 complex subunit sigma (AP2S1)

Interactions
Interaction #1 OPRD1 - AP2S1

Interfaces
(1) TRG_LysEnd_APsAcLL_1 motif (241RSVRLL246) in Delta-type opioid receptor (OPRD1)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)

Interaction Regulation
Effector binding Induction (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the Delta-type opioid receptor (OPRD1) TRG_LysEnd_APsAcLL_1 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction

Context
Switch localisation
ELM curated: Endocytic vesicle, cytosol
References

(1) The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells.
Wang et al. J. Biol. Chem. (2003)




Loading visualisation

↑