Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (Ap2s1) subunit for recruitment of T-cell surface glycoprotein CD3 gamma chain (Cd3g) via an endocytosis motif.
Participants: (1) T-cell surface glycoprotein CD3 gamma chain (Cd3g) (2) AP-2 complex subunit sigma (Ap2s1)
(1) A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.Letourneur et al. Cell (1992) (2) Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.Dietrich et al. J. Cell Biol. (1997) (3) Masking of the CD3 gamma di-leucine-based motif by zeta is required for efficient T-cell receptor expression.Lauritsen et al. Traffic (2004)
