Switches.ELM

Switch #:

SWTI000238

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S112 in the 14-3-3 binding motif of Yorkie homolog (Yap1) induces binding to the 14-3-3 protein epsilon (Ywhae) protein. 14-3-3 retains phosphorylated YAP in the cytosol, negatively regulating its function.

Participants:
(1) Yorkie homolog (Yap1)
(2) 14-3-3 protein epsilon (Ywhae)

Interactions

Interaction #1 Yap1 - Ywhae

Interfaces
(1) LIG_14-3-3_1 motif (₁₀₉RAHSSP₁₁₄) in Yorkie homolog (Yap1)
(2) 14-3-3 protein_(4-239) in 14-3-3 protein epsilon (Ywhae)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₁₁₂ on Yorkie homolog (Yap1)) of the Yorkie homolog (Yap1) LIG_14-3-3_1 motif - 14-3-3 protein epsilon (Ywhae) 14-3-3 protein interaction

Context

Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane

References

(1) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
Kanai et al. EMBO J. (2000)

(2) Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms.
Ren et al. Dev. Biol. (2010)