Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Protein Nef (nef) via an endocytosis motif.
Participants: (1) Protein Nef (nef) (2) AP-2 complex subunit sigma (AP2S1)
(1) A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.Bresnahan et al. Curr. Biol. (1998) (2) Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.Craig et al. Proc. Natl. Acad. Sci. U.S.A. (1998)
