Switch #:
SWTI000236
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Nef protein (nef) via an endocytosis motif.

Participants:
(1) Nef protein (nef)
(2) AP-2 complex subunit sigma (AP2S1)

Interactions
Interaction #1 nef - AP2S1

Interfaces
(1) TRG_LysEnd_APsAcLL_1 motif (160ENTSLL165) in Nef protein (nef)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)

Interaction Regulation
Effector binding Induction (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the Nef protein (nef) TRG_LysEnd_APsAcLL_1 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction

Context
Switch localisation
ELM curated: Endocytic vesicle, cytosol
Inferred: cytosol
References

(1) Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.
Craig et al. Proc. Natl. Acad. Sci. U.S.A. (1998)




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