Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Cytotoxic T-lymphocyte protein 4 (CTLA4) via an endocytosis motif.
Participants: (1) Cytotoxic T-lymphocyte protein 4 (CTLA4) (2) AP-2 complex subunit mu (AP2M1)
(1) Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.Shiratori et al. Immunity (1997)
