Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Asialoglycoprotein receptor 1 (ASGR1) via an endocytosis motif.
Participants: (1) Asialoglycoprotein receptor 1 (ASGR1) (2) AP-2 complex subunit mu (AP2M1)
(1) Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits.Fuhrer et al. J. Cell Biol. (1991) (2) Related signals for endocytosis and basolateral sorting of the asialoglycoprotein receptor.Geffen et al. J. Biol. Chem. (1993)
