Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Transferrin receptor protein 1 (TFRC) via an endocytosis motif.
Participants: (1) Transferrin receptor protein 1 (TFRC) (2) AP-2 complex subunit mu (AP2M1)
(1) A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.Alvarez et al. Biochem. J. (1990) (2) Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.Jing et al. J. Cell Biol. (1990) (3) YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.Collawn et al. J. Biol. Chem. (1993)
