Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Epidermal growth factor receptor (EGFR) via an endocytosis motif.
Participants: (1) Epidermal growth factor receptor (EGFR) (2) AP-2 complex subunit mu (AP2M1)
(1) Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.Nesterov et al. EMBO J. (1999)
Your browser does not support iframes.