Switch #:
SWTI000221
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Epidermal growth factor receptor (EGFR) via an endocytosis motif.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) AP-2 complex subunit mu (AP2M1)

Interactions
Context
References

(1) Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.
Nesterov et al. EMBO J. (1999)




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