Switch #:
SWTI000220
Switch type:
Binary
Switch subtype:
Allostery

Description:
Phosphorylation of cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) at S11 shifts the conformational equilibrium to the myristoyl-out conformation, making the myristoyl moiety available for interaction with the membrane.

Participants:
(1) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
(2) membrane

Interactions
Interaction #1 PRKACA - membrane

Interfaces
(1) MOD_NMyristoyl motif (1MGNAAAA7) in cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
(2) membrane

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S11 on cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)) of the cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) MOD_NMyristoyl motif - membrane interaction

Additional Information
Structural information: 1CMK
Context
References

(1) A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes.
Gaffarogullari et al. J. Mol. Biol. (2011)

(2) Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Zheng et al. Protein Sci. (1993)




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