Description: Binding of Ezrin (EZR) via its FERM domain to the EB domain of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) results in allosteric coupling to the second PDZ domain of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1), which results in relief of the intramolecular interaction with the PDZ binding ligand, thereby increasing the affinity of the PDZ domain for other ligands, including Catenin beta-1 (CTNNB1).
Participants: (1) Catenin beta-1 (CTNNB1) (2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
(1) A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.Bhattacharya et al. J. Biol. Chem. (2010)
