Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of T-cell surface glycoprotein CD4 (CD4) via an endocytosis motif.
Participants: (1) T-cell surface glycoprotein CD4 (CD4) (2) AP-2 complex subunit sigma (AP2S1)
(1) A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.Jackson et al. Cell (2010)
