Switch #:
SWTI000216
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of Beta-arrestin-1 (ARRB1) to ligand-induced, phosphorylated GPCRs results in a conformational change that makes the AP2-beta interaction motif in Beta-arrestin-1 (ARRB1) accessible for binding to AP-2 complex subunit beta (AP2B1), which mediates internalization of the GPCR.

Participants:
(1) Beta-arrestin-1 (ARRB1)
(2) AP-2 complex subunit beta (AP2B1)

Interactions
Interaction #1 ARRB1 - AP2B1

Interfaces
(1) TRG_AP2beta_CARGO_1 motif (385DIVFEDFARQR395) in Beta-arrestin-1 (ARRB1)
(2) Beta2-adaptin appendage, C-terminal sub-domain (826-936) in AP-2 complex subunit beta (AP2B1)

Interaction Regulation
Effector binding Induction of the Beta-arrestin-1 (ARRB1) TRG_AP2beta_CARGO_1 motif - AP-2 complex subunit beta (AP2B1) Beta2-adaptin appendage, C-terminal sub-domain interaction

Additional Information
Structural information: 1G4M
Context
References

(1) Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
Edeling et al. Dev. Cell (2006)




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