Description: Ligand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation.
Participants: (1) T-cell surface glycoprotein CD3 epsilon chain (CD3E) (2) Cytoplasmic protein NCK2 (NCK2)
(1) Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.Gil et al. Cell (2002)
