Switch #:
SWTI000211
Switch type:
Uncategorised
Switch subtype:
Uncategorised

Description:
Phosphorylation of Neural Wiskott-Aldrich syndrome protein (WASL) at Y256 destabilises the auto-inhibitory intramolecular interaction of Neural Wiskott-Aldrich syndrome protein (WASL).

Participants:
(1) Neural Wiskott-Aldrich syndrome protein (WASL)

Interactions
Interaction #1 WASL - WASL(intramolecular)
intramolecular
Interfaces
(1) ELM:LIG_GBD_WASP_1 motif (467IVGALMEVMQK477) in Neural Wiskott-Aldrich syndrome protein (WASL)
(2) P21-Rho-binding domain (202-261) in Neural Wiskott-Aldrich syndrome protein (WASL)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of Y256 on Neural Wiskott-Aldrich syndrome protein (WASL)) of the Neural Wiskott-Aldrich syndrome protein (WASL) LIG_GBD_WASP_1 motif - Neural Wiskott-Aldrich syndrome protein (WASL) P21-Rho-binding domain interaction


References

(1) Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Torres et al. J. Biol. Chem. (2006)

(2) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

(3) Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
Yokoyama et al. J. Biol. Chem. (2005)




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