Description: Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).
Participants: (1) Wiskott-Aldrich syndrome protein (WAS)
(1) Physical mechanisms of signal integration by WASP family proteins.Padrick et al. Annu. Rev. Biochem. (2010) (2) Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.Torres et al. Mol. Cell (2003) (3) Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.Torres et al. J. Biol. Chem. (2006) (4) Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.Cory et al. J. Biol. Chem. (2002) (5) Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.Badour et al. J. Exp. Med. (2004)
