Switch #:
SWTI000207
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S443 in the PDZ-binding motif of Inward rectifier potassium channel 4 (KCNJ4) by inhibits its interaction with the Disks large homolog 4 (DLG4) protein.

Participants:
(1) Inward rectifier potassium channel 4 (KCNJ4)
(2) Disks large homolog 4 (DLG4)

Interactions
Interaction #1 KCNJ4 - DLG4

Interfaces
(1) LIG_PDZ_Class_1 motif (440RRESAI445) in Inward rectifier potassium channel 4 (KCNJ4)
(2) PDZ domain (Also known as DHR or GLGF) (160-244) in Disks large homolog 4 (DLG4)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S443 on Inward rectifier potassium channel 4 (KCNJ4)) of the Inward rectifier potassium channel 4 (KCNJ4) LIG_PDZ_Class_1 motif - Disks large homolog 4 (DLG4) PDZ domain (Also known as DHR or GLGF) interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S443: cAMP subfamily

Context
References

(1) Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation.
Cohen et al. Neuron (1996)




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