Switch #:
SWTI000206
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S410 in the RhoGAP-binding motif of DCC-interacting protein 13-alpha (APPL1) inhibits its interaction with Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL).

Participants:
(1) DCC-interacting protein 13-alpha (APPL1)
(2) Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL)

Interactions
Interaction #1 APPL1 - OCRL

Interfaces
(1) ELM:LIG_RhoGAP_OCRL_1 motif (403SFQQRHESLRPAA415) in DCC-interacting protein 13-alpha (APPL1)
(2) RhoGAP domain (735-878) in Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S410 on DCC-interacting protein 13-alpha (APPL1)) of the DCC-interacting protein 13-alpha (APPL1) LIG_RhoGAP_OCRL_1 motif - Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) RhoGAP domain interaction


Additional Information
Affinity : S410: 43.1 µM, pS410: N.D. µM
Context
References

(1) A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.
Erdmann et al. Dev. Cell (2007)

(2) Recognition of the F&H motif by the Lowe syndrome protein OCRL.
Pirruccello et al. Nat. Struct. Mol. Biol. (2011)




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