Switch #:
SWTI000192
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S650 in the PTB-binding motif of Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) blocks its interaction with Talin-1 (TLN1). Phosphorylation of Y649 by Src kinase enhances the interaction, possibly indirectly by inhibiting S650 phosphorylation.

Participants:
(1) Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C)
(2) Talin-1 (TLN1)

Interactions
Interaction #1 PIP5K1C - TLN1

Interfaces
(1) ELM:LIG_PTB_Talin motif (650SPLH653) in Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C)
(2) PTB domain (IRS-1 type) (310-401) in Talin-1 (TLN1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S650 on Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C)) of the Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) LIG_PTB_Talin motif - Talin-1 (TLN1) PTB domain (IRS-1 type) interaction

Context
Switch localisation
Inferred: cytosol, focal adhesion, ruffle membrane


Switch pathways
Inferred: Focal adhesion
References

(1) Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases.
Lee et al. J. Cell Biol. (2005)




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