Switches.ELM

Switch #:

SWTI000191

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of the LC4 region of Sorting nexin-9 (SNX9) abolishes its interaction with Fructose-bisphosphate aldolase A (ALDOA). However, the exact position of the residues that are phosphorylated and regulate binding is not known.

Participants:
(1) Sorting nexin-9 (SNX9)
(2) Fructose-bisphosphate aldolase A (ALDOA)

Interactions

Interaction #1 SNX9 - ALDOA

Interfaces
(1) ELM:LIG_Glycolytic_Aldolase motif (₁₆₅WDEDW₁₆₉) in Sorting nexin-9 (SNX9)
(2) Fructose-bisphosphate aldolase class-I_(15-364) in Fructose-bisphosphate aldolase A (ALDOA)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of Y₁₅₄, T₁₅₉, S₁₇₄, S₁₇₅, S₁₇₆, Y₁₇₇, S₁₈₁ and S₁₈₃ on Sorting nexin-9 (SNX9)) of the Sorting nexin-9 (SNX9) LIG_Glycolytic_Aldolase motif - Fructose-bisphosphate aldolase A (ALDOA) Fructose-bisphosphate aldolase class-I interaction

References

(1) Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.
Lundmark et al. J. Biol. Chem. (2004)