Switch #:
SWTI000189
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S257 in the 14-3-3-binding motif of RAF proto-oncogene serine/threonine-protein kinase (RAF1) abolishes binding of the motif, phosphorylated at S259, to 14-3-3 protein zeta/delta (YWHAZ).

Participants:
(1) RAF proto-oncogene serine/threonine-protein kinase (RAF1)
(2) 14-3-3 protein zeta/delta (YWHAZ)

Interactions
Interaction #1 RAF1 - YWHAZ

Interfaces
(1) LIG_14-3-3_1 motif (256RSTSTP261) in RAF proto-oncogene serine/threonine-protein kinase (RAF1)
(2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S257 on RAF proto-oncogene serine/threonine-protein kinase (RAF1)) of the RAF proto-oncogene serine/threonine-protein kinase (RAF1) LIG_14-3-3_1 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction

Context
Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane
Inferred: cytosol


Switch pathways
Inferred: PI3K-Akt signaling pathway
References

(1) Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
Muslin et al. Cell (1996)




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