Switch #:
SWTI000186
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).

Participants:
(1) M-phase inducer phosphatase 3 (CDC25C)
(2) Exportin-1 (XPO1)

Interactions
Interaction #1 CDC25C - XPO1

Interfaces
(1) TRG_NES_CRM1_1 motif (189EISDELMEFSLKDQE203) in M-phase inducer phosphatase 3 (CDC25C)
(2) Exportin 1-like protein (123-268) in Exportin-1 (XPO1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S198 on M-phase inducer phosphatase 3 (CDC25C)) of the M-phase inducer phosphatase 3 (CDC25C) TRG_NES_CRM1_1 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S198: Serine/threonine-protein kinase PLK1 (PLK1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S198 : Serine/threonine-protein kinase PLK1 (PLK1), Serine/threonine-protein kinase PLK3 (PLK3).

Context
Switch localisation
Curated: nucleus
ELM curated: nucleus, cytosol
Inferred: cytosol, nucleoplasm

Switch cell cycle phase
Curated: G2/M transition of mitotic cell cycle
References

(1) Plk1 promotes nuclear translocation of human Cdc25C during prophase.
Toyoshima-Morimoto et al. EMBO Rep. (2002)




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