Description: Phosphorylation of S152 adjacent to the NLS of Phosphate system positive regulatory protein PHO4 (PHO4) by the Pho80-Pho85 CDK-Cyclin complex inhibits nuclear import this protein by blocking its interaction with Importin subunit beta-3 (PSE1). Upon phosphate starvation, Pho81 inhibits the Pho80-Pho85 complex, leading to translocation of Phosphate system positive regulatory protein PHO4 (PHO4) to the nucleus, where it regulates expression of phosphate-responsive genes.
Participants: (1) Phosphate system positive regulatory protein PHO4 (PHO4) (2) Importin subunit beta-3 (PSE1)
(1) Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.Kaffman et al. Genes Dev. (1998)
