Switch #:
SWTI000170
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T186 in the Pin1-binding motif of Wee1-like protein kinase 1-B (wee1-b) induces binding to the pin1 protein.

Participants:
(1) Wee1-like protein kinase 1-B (wee1-b)
(2) pin1

Interactions
Interaction #1 wee1-b - pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (183NPFTPD188) in Wee1-like protein kinase 1-B (wee1-b)
(2) WW domain (7-37) in pin1

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T186 on Wee1-like protein kinase 1-B (wee1-b)) of the Wee1-like protein kinase 1-B (wee1-b) DOC_WW_Pin1_4 motif - pin1 WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase.
Okamoto et al. Proc. Natl. Acad. Sci. U.S.A. (2007)




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