Switch #:
SWTI000169
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) F-box only protein 5 (FBXO5)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions
Interaction #1 FBXO5 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (144DSGYSS149) in F-box only protein 5 (FBXO5)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S145 and S149 on F-box only protein 5 (FBXO5)) of the F-box only protein 5 (FBXO5) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S145 : Serine/threonine-protein kinase PLK1 (PLK1). S149 : Serine/threonine-protein kinase PLK1 (PLK1).

Context
Switch localisation
Curated: cytosol
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
Inferred: cytosol

Switch cell cycle phase
Curated: prophase
References

(1) Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.
Guardavaccaro et al. Dev. Cell (2003)




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