Description: Dual phosphorylation of S19 and S23 in the TrCP1-binding motif of NF-kappa-B inhibitor beta (NFKBIB) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Participants: (1) NF-kappa-B inhibitor beta (NFKBIB) (2) F-box/WD repeat-containing protein 1A (BTRC)
(1) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.Shirane et al. J. Biol. Chem. (1999)
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