Switches.ELM

Switch #:

SWTI000154

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T398 in the PIF pocket-binding motif of Rho-associated protein kinase 1 (ROCK1) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Rho-associated protein kinase 1 (ROCK1)

Interactions

Interaction #1 ROCK1 - ROCK1(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (₃₉₄FVGFTY₃₉₉) in Rho-associated protein kinase 1 (ROCK1)
(2) Protein kinase domain_(76-338) in Rho-associated protein kinase 1 (ROCK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T₃₉₈ on Rho-associated protein kinase 1 (ROCK1)) of the Rho-associated protein kinase 1 (ROCK1) DOC_AGCK_PIF_1 motif - Rho-associated protein kinase 1 (ROCK1) Protein kinase domain interaction

Context

Switch localisation
ELM curated: cytosol, internal side of plasma membrane

References

(1) PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.
Pinner et al. Nat. Cell Biol. (2008)