Switch #:
SWTI000152
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S474 in the PIF pocket-binding motif of RAC-beta serine/threonine-protein kinase (AKT2) induces intramolecular binding and kinase cis-activation.

Participants:
(1) RAC-beta serine/threonine-protein kinase (AKT2)

Interactions
Interaction #1 AKT2 - AKT2(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (470FPQFSY475) in RAC-beta serine/threonine-protein kinase (AKT2)
(2) Protein kinase domain (152-409) in RAC-beta serine/threonine-protein kinase (AKT2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S474 on RAC-beta serine/threonine-protein kinase (AKT2)) of the RAC-beta serine/threonine-protein kinase (AKT2) DOC_AGCK_PIF_1 motif - RAC-beta serine/threonine-protein kinase (AKT2) Protein kinase domain interaction

Additional Information
Structural information: 1O6L
Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane
References

(1) Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
Yang et al. Nat. Struct. Biol. (2002)




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