Switch #:
SWTI000140
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Integrin beta-3 (ITGB3)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 ITGB3 - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (779TFTNITY785) in Integrin beta-3 (ITGB3)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y785 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y785 : Tyrosine-protein kinase SYK (SYK), Proto-oncogene tyrosine-protein kinase Src (SRC).

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex


Switch pathways
Inferred: Focal adhesion
References

(1) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh et al. J. Biol. Chem. (2010)




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