Switch #:
SWTI000139
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.

Participants:
(1) Integrin beta-3 (ITGB3)
(2) Docking protein 1 (DOK1)

Interactions
Interaction #1 ITGB3 - DOK1

Interfaces
(1) LIG_PTB_Phospho_1 motif (767TANNPLY773) in Integrin beta-3 (ITGB3)
(2) PTB domain (IRS-1 type) (151-254) in Docking protein 1 (DOK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y773 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - Docking protein 1 (DOK1) PTB domain (IRS-1 type) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y773 : Proto-oncogene tyrosine-protein kinase Src (SRC).

Additional Information
Structural information: 2L1C
Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
References

(1) Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
Calderwood et al. Proc. Natl. Acad. Sci. U.S.A. (2003)

(2) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh et al. J. Biol. Chem. (2010)

(3) An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.
Oxley et al. J. Biol. Chem. (2008)




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