Description: Phosphorylation of Y773 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the Docking protein 1 (DOK1) protein.
Participants: (1) Integrin beta-3 (ITGB3) (2) Docking protein 1 (DOK1)
(1) Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.Calderwood et al. Proc. Natl. Acad. Sci. U.S.A. (2003) (2) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.Deshmukh et al. J. Biol. Chem. (2010) (3) An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.Oxley et al. J. Biol. Chem. (2008)
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