Switch #:
SWTI000137
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y497 in the PTB-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Insulin receptor substrate 1 (IRS1) protein.

Participants:
(1) Interleukin-4 receptor subunit alpha (IL4R)
(2) Insulin receptor substrate 1 (IRS1)

Interactions
Interaction #1 IL4R - IRS1

Interfaces
(1) LIG_PTB_Phospho_1 motif (491IAGNPAY497) in Interleukin-4 receptor subunit alpha (IL4R)
(2) PTB domain (IRS-1 type) (160-262) in Insulin receptor substrate 1 (IRS1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y497 on Interleukin-4 receptor subunit alpha (IL4R)) of the Interleukin-4 receptor subunit alpha (IL4R) LIG_PTB_Phospho_1 motif - Insulin receptor substrate 1 (IRS1) PTB domain (IRS-1 type) interaction

Additional Information
Structural information: 1IRS
Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex


Switch pathways
Inferred: PI3K-Akt signaling pathway
References

(1) FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation.
Nelms et al. Immunity (1998)

(2) Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Zhou et al. Nat. Struct. Biol. (1996)




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