Description: Phosphorylation of Y497 in the PTB-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Insulin receptor substrate 1 (IRS1) protein.
Participants: (1) Interleukin-4 receptor subunit alpha (IL4R) (2) Insulin receptor substrate 1 (IRS1)
(1) FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation.Nelms et al. Immunity (1998) (2) Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.Zhou et al. Nat. Struct. Biol. (1996)
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