Switch #:
SWTI000132
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T231 in the FHA-binding motif of DNA repair protein XRCC4 (Xrcc4) induces binding to the Bifunctional polynucleotide phosphatase/kinase (Pnkp) protein.

Participants:
(1) DNA repair protein XRCC4 (Xrcc4)
(2) Bifunctional polynucleotide phosphatase/kinase (Pnkp)

Interactions
Interaction #1 Xrcc4 - Pnkp

Interfaces
(1) LIG_FHA_2 motif (229GSTDEES235) in DNA repair protein XRCC4 (Xrcc4)
(2) Bifunctional polynucleotide phosphatase/kinase (Pnkp)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T231 on DNA repair protein XRCC4 (Xrcc4)) of the DNA repair protein XRCC4 (Xrcc4) LIG_FHA_2 motif - Bifunctional polynucleotide phosphatase/kinase (Pnkp) interaction

Context
Switch localisation
ELM curated: nucleus, Replication fork
References

(1) The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Bernstein et al. Mol. Cell (2005)




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